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A Nature Research Journal. Somatic mutations in the mitochondrial genome mtDNA have been linked to multiple disease conditions and to ageing itself. In Drosophila , knock-in of a proofreading deficient mtDNA polymerase POLG generates high levels of somatic point mutations and also small indels, but surprisingly limited impact on organismal longevity or fitness. In these flies, the presence of multiple non-synonymous substitutions, even at modest heteroplasmy, disrupts mitochondrial function and dramatically impacts organismal fitness.
A detailed analysis of the mutation profile in the POLG and mito-APOBEC1 models reveals that mutation type quality rather than quantity is a critical factor in impacting organismal fitness.
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In addition to the main questions outlined in the project ToR and the Inception Note around the FTRP’s effectiveness, efficiency and relevance to date, the Review.
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T here is still reason to believe the growing coronavirus outbreak in China can be contained, a top World Health Organization official said Saturday, pointing to some evidence that the disease may not be spreading as rapidly as is feared. He also downplayed reports that people infected with the virus may be contagious before they show symptoms — a feature that, if true, would make it much harder to control. The WHO declared the outbreak a global health emergency on Thursday.
Likewise, there has not been a lot of spread from cases discovered in other countries in tourists from China or people returning from China. Still, numbers of cases are growing in big leaps — China reported 2, new cases and 46 additional deaths on Saturday. And those numbers might be higher still but for the fact that China has a backlog of tests to be processed.
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